WebTachyphylaxis is a medical term describing an acute, sudden decrease in response to a drug after its administration;[1] i.e. a rapid and short-term onset of drug tolerance. It can occur after an initial dose or after a series of small doses. Increasing the dose of the drug may be able to restore the original response.[2] WebTreatment options include slowly tapering opioid doses, switching to longer-acting opioids, or specifically treating the symptoms of opioid withdrawal. Novel therapies may also …
Can Opioid Tolerance Be Treated by Increasing the Opioid Dose?
WebMay 9, 2016 · Opioids commonly cause constipation, distension, and ileum. This may be particularly problematic among relatively immobile critically ill patients. Occasionally it … WebObjective: After prolonged opioid exposure, children develop opioid-induced hyperalgesia, tolerance, and withdrawal. Strategies for prevention and management should be based on the mechanisms of opioid tolerance and withdrawal. Patients and methods: Relevant manuscripts published in the English language were searched in Medline by using search … legend css central unit
Opioid receptor desensitization: mechanisms and its link …
WebMay 30, 2024 · Fentanyl (which can also be spelled fentanil) is a potent synthetic opioid similar to morphine but produces analgesia to a greater extent. This robust pharmacologic agent is typically 50 to 100 times more potent than morphine. A dose of only 100 micrograms can produce equivalent analgesia to approximately 10 mg of morphine. WebFeb 13, 2024 · Drug tolerance and tachyphylaxis. The effect of a drug can decrease with repeated dosing: Drug tolerance (e.g., opioids, benzodiazepines, barbiturates, alcohol) The mechanisms responsible for the development of drug tolerance include: Down-regulation of receptors; Increased synthesis of enzymes that metabolize the drug; Can be overcome by ... WebTachyphylaxis ( Greek ταχύς, tachys, "rapid", and φύλαξις, phylaxis, "protection") is a medical term describing an acute, sudden decrease in response to a drug after its administration; [1] i.e. a rapid and short-term onset of drug tolerance. It can occur after an initial dose or after a series of small doses. legend crossword clue