WebModular polyketide synthases (PKSs) are polymerases that employ α-carboxyacyl-CoAs as extender substrates. This enzyme family contains several catalytic modules, where each module is responsible for a single round of polyketide chain extension. Although PKS modules typically use malonyl-CoA or methylmalonyl-CoA for chain elongation, many … WebUsing synthetic biology, we create tailor-made, engineered endolysins and tail fibers with the ultimate goal to kill multidrug-resistant cells. In addition, we use phage genome engineering to create smart phages with modified phage proteins, addressing current hurdles in …
An Endolysin Salmcide‐p1 from Bacteriophage fmb‐p1 against …
WebJan 26, 2024 · The modification of phage endolysin by gene engineering to lyse Gram-negative bacteria is a novel and effective strategy. Wang et al. fused the Lysep3 with the cell wall binding domain D8, and the... WebSynthetic biology of modular endolysins. Journal Contribution - Journal Article ... pictures jennifer gober
Applied Biotechnology Research group — Department of …
WebOct 20, 2024 · Endolysins are hydrolases produced by phages which function in vivo to lyse bacterial cell walls and release progeny phages at the end of a replication cycle [ 11 ]. These enzymes are remarkably efficient in hydrolyzing the peptidoglycan layer, resulting in a sudden drop in turgor pressure and osmotic lysis to cause bacterial cell death [ 12 ]. WebApr 1, 2024 · Synthetic biology represents a new and innovative way of generating ‘user-controlled’ genetic circuits to overcome limitations imposed by nature. In the realm of immune cell programming, synthetic biology has significantly impacted the development of chimeric antigen receptor (CAR) T cells []. These CARs offer a modular design that can be ... WebMay 15, 2012 · KZ144 and EL188 possess a modular structure composed of an N-terminal cell wall binding domain and a C-terminal catalytic domain which is rare amongst … topgolf twin cities