All STAT molecules are phosphorylated by receptor associated kinases, that causes activation, dimerization by forming homo- or heterodimers and finally translocate to nucleus to work as transcription factors. Specifically STAT1 can be activated by several ligands such as Interferon alpha (IFNα), Interferon gamma (IFNγ), Epidermal Growth Factor (EGF), Platelet Derived Growth Factor (PDGF), Interleukin 6 (IL-6), or IL-27. WebJan 29, 2024 · To activate the transcription of IFN-γ stimulated genes, STAT1 needs to be localized in the nuclei and recognizes the gamma-activated sites (GAS) of these genes . If UL23 interaction of Nmi leads to the cytoplasmic accumulation of STAT1, it is expected that expression of UL23 may inhibit the STAT1-dependent transcription of IFN-γ stimulated ...
IFNγ: signalling, epigenetics and roles in immunity ... - Nature
WebJun 19, 2024 · Signalling by the JAK–STAT pathway, including activation of STAT1 by IFNγ, is typically transient, with a peak signal occurring at 15–60 minutes and resolution back to baseline occurring at 2–4... WebSep 1, 1998 · Biochemical and genetic analysis has demonstrated that Stat1 is essential for gene activation in response to interferon stimulation. Although progress has been made … thomas aeschi familie
STAT1 and STAT3 in Tumorigenesis: Two Sides of the …
WebNov 23, 1999 · As shown above, the kinetics of p38 MAPK activation and STAT1 Ser727 phosphorylation can be separated by ≈10 min. For these reasons, we considered the … WebApr 14, 2024 · The transcription factor STAT1 plays an essential role in antiviral innate immunity in the response to type I and III IFNs. Next, we examined the activation of STAT1 in LINC02574 knockdown cells and control cells. LINC02574 knockdown resulted in significantly decreased activation and expression of STAT1 (Figure 6J). Since LINC02574 … WebApr 4, 2024 · STAT1 activation within macrophages is required for M1 macrophage activation and anti-C. neoformans activity via the production of nitric oxide. transcriptional activation of Adar1 by IFN occurs in the absence of STAT1 by a non-canonical STAT2-dependent pathway in mouse but not human cells. thomas a falk