2024 Nis thyroid

Nis thyroid

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August undefined, 2024

WebFeb 1, 2014 · The Na + /I − symporter (NIS) is the plasma membrane glycoprotein that mediates active I − transport in the thyroid and other tissues, such as salivary glands, stomach, lactating breast, and small intestine. http://www.ninmas.org/eng/thyroid.html

The Role of the NIS (SLC5A5) Gene in Papillary Thyroid Cancer: A ...

WebNov 7, 2014 · B-RafV600E mutant is found in 40–70% of papillary thyroid carcinoma (PTC) and has an important role in the pathogenesis of PTC. The sodium iodide symporter (NIS) is an integral plasma membrane ... WebOct 12, 2024 · The NIS is a membrane glycoprotein that transports two sodium ions and one iodide ion into the cytosol of benign and tumorous thyroid cells from extracellular fluid (1–3). Since radioiodine also can be taken up by the NIS, radioiodine can be used to visualize or selectively kill DTC cells. christie\u0027s ann and gordon getty

分子靶向药物治疗难治性甲状腺癌的疗效及安全性的meta分析

WebJul 15, 2024 · Most thyroid imaging techniques capitalize on some phase of hormone synthesis within the thyroid gland. Iodides or iodide analogs are actively transported by the glycoprotein sodium iodide symporter (NIS) … WebIodine is a mineralfound in some foods. The body needs iodine to make thyroid hormones. These hormones control the body's metabolism and many other important functions. The body also needs thyroid hormones for proper bone … WebOct 31, 2012 · NIS-mediated iodide uptake also forms the basis for the diagnostic nuclear imaging and radioiodine therapy for thyroid diseases. Radioiodine therapy following NIS gene transfer was shown to be efficient in nonthyroid, especially, liver cancer models. NIS is expressed in many cancers, among them cancer of the thyroid, breast, and liver . ge profile wifi dishwasher

Autoregulation of thyroid-specific gene transcription by ... - PNAS

WebFeb 9, 2024 · The main function of the thyroid gland is to synthesize and secrete thyroid hormone (TH), which is important for growth, differentiation, development, and metabolism [].Iodine is an intrinsic component of TH [], and iodide is the only iodine-derived anion species that can be transported by sodium/iodide symporter (NIS) on the membrane of … Webremains unclear. To gain insight into the function of nominally thyroid-specific genes in skin, we analyzed the expression of thyroid-stimulating hormone–receptor (TSH-R), thyroglobulin (Tg), sodium iodide symporter (NIS), and thyroperoxidase (TPO) genes in normal human skin biopsies and cultured primary keratinocytes and dermal fibroblasts. ge profile wifi stoveWebFeb 10, 2024 · Active iodide (I-) transport in both the thyroid and some extrathyroidal tissues is mediated by the Na + /I-symporter (NIS). In the thyroid, NIS-mediated I-uptake plays a pivotal role in thyroid hormone (TH) biosynthesis. THs are key during embryonic and … christie\u0027s andy warhol

"WebIodide is accrued from the blood into thyroidal cells through the sodium/iodide symporter (NIS). It is attached to the tyrosyl residue of TG through the action of thyroid peroxidase (TPO) in the presence of hydrogen peroxide (H2 O 2). " - Nis thyroid

Nis thyroid

$Redifferentiation of Radioiodine Refractory Differentiated Thyroid ...$

WebJan 28, 2024 · Recently, ER stress induced by tunicamycin (TM) was reported to inhibit the expression of key genes involved in thyroid hormone synthesis, such as sodium/iodide symporter (NIS), thyroid peroxidase (TPO) and thyroglobulin (TG), and their regulators such as thyrotropin receptor (TSHR), thyroid transcription factor-1 (TTF-1), thyroid transcription … WebMay 10, 2024 · The pathway controls the expression of NIS, Tg, TPO and TSHR, through thyroid-specific transcription factors , and regulates Tg macrocytosis and …

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WebAbstract. The sodium/iodide symporter (NIS) is an intrinsic plasma membrane protein that mediates active iodide transport into the thyroid gland and into several extrathyroidal … WebMar 31, 2024 · The results indicated that nevirapine significantly inhibited the proliferation and increased the expressions of thyroid differentiation-related genes, thyroid stimulating hormone receptor (TSHR), sodium/iodide symporter (NIS), thyroid peroxidase (TPO), and transcriptional factor paired box 8 (PAX8) in dedifferentiated thyroid cancer cells (WRO …

WebThe rat thyroid model was then extrapolated to humans using human . in vitro . HTS data for NIS inhibition and the chemical specific hepatic clearance rate in humans. The overall species extrapolated PBPK-thyroid kinetics model can be used to predict dose-response (% drop in thyroid serum levels compared to homeostasis) relationships in humans. WebApr 5, 2024 · Purpose Most differentiated thyroid cancer (DTC) patients have a good prognosis after surgery, but radioiodine refractory differentiated thyroid cancer (RAIR …

Web主要取决于nis的功能. 然而. 低分化癌是失分化的甲状腺癌. 影响nis的调节并降低功能性nis表达. 因此核素显像中. 甲状腺癌往往表现为摄取差的冷结节. 相关文章： 7-36：ect、pet-ct显像下甲状腺“热、温、凉、冷”结节与甲状腺癌关系. 为了增强甲状腺癌的摄碘性 ... WebJan 4, 2024 · Regulating iodine to modulate NIS function can lower the risk of developing thyroid disease and, in some cases, can reverse the disease even after it is established. The degree of the problem is amplified by how dissatisfied patients are with current thyroid treatments. 6 A large survey was conducted on over 12 000 women between the ages of …

WebOct 18, 2024 · NSAIDs reduce pain and inflammation in the body by blocking enzymes called cyclooxygenases , which are involved in the function of platelets (blood cells that help … ge profile white countertop microwaveWebMay 30, 2014 · Iodide transport in thyroid cells As illustrated in Figure 1, the NIS ( SLC5A5), a member of the solute carrier family 5, located at the basolateral plasma membrane of the thyroid follicular cells actively transports iodide into the thyroid using the electrochemical gradient generated by the Na,K-ATPase [ 9 – 11 ]. ge profile wifi ovenWebJul 15, 2024 · Iodide is a fundamental component of thyroid hormone and is actively imported into thyroid follicular cells by a basilar membrane-bound protein, the sodium-iodide symporter (NIS) . A functional NIS is required for the active concentration of radioactive iodine within the thyroid gland where it is incorporated into colloid and degrades into beta ... ge profile wine chillersWebFeb 27, 2024 · Conclusions: The findings of this preclinical study showed that ALK fusion-induced downregulation of NIS, the prerequisite of RAI refractoriness, could be reversed in thyroid cells by either direct inhibition of ALK or its downstream signaling pathways. christie\\u0027s archivesWebJan 28, 2024 · Recently, ER stress induced by tunicamycin (TM) was reported to inhibit the expression of key genes involved in thyroid hormone synthesis, such as sodium/iodide … ge profile wifi connectWebMay 27, 1997 · The cDNA encoding NIS was recently cloned by functional screening of a cDNA library from a rat thyroid-derived cell line (FRTL-5 cells) in Xenopus laevis oocytes … ge profile wine cooler troubleshootingWebThe Na + /I − symporter (NIS) catalyzes the accumulation of iodide into thyroid cells, an essential step in the biosynthesis of thyroid hormones. As a result of the isolation of the rat NIS cDNA, steadfast advances in the study of NIS at the molecular level have resulted in the following accomplishments: generation of high-affinity anti-NIS antibodies, elucidation of … ge profile wine coolers under counter